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In simple terms, the respiratory system comprises of organs, blood vessels, muscles and airways which are in control of the movement of oxygen and carbon dioxide. The key conditions that are covered in this area are asthma, chronic obstructive pulmonary disease (COPD), allergies and common issues such as coughs, colds, and respiratory infections.
During your studies you will find a slight overlap between infections and this section, so it is a good way to reinforce some of your learning (if you have previously thoroughly studied the infections section before tackling this part). Some of the respiratory system infections will include: bronchitis, acute exacerbation of COPD, pneumonia, sinusitis, and influenza.
There is a large variety of drug classes to focus on in this section which include some of the following: bronchodilators, corticosteroids, leukotriene receptor antagonists, mucolytics, antihistamines, antifibrotics, nasal decongestants, and antibacterials.
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XANTHINE: THEOPHYLLNE | |||
Drug action | What is it used for? | Cautions | Signs of toxicity |
·       Inhibits type III and type IV phosphodiesterase (PDE) ·       Reduces break down of adenosine monophosphate (cAMP) in smooth muscle cells ·       Leads to bronchodilation | ·       Reversible airways obstruction ·       Severe acute/chronic asthma | ·       Cardiac arrhythmias/conditions ·       Elderly (plasma-theophylline concentration is increased in adults) ·       Epilepsy ·       Fever ·       Hypertension ·       Peptic ulcer ·       Thyroid disorder | ·       Vomiting, haematemesis (vomiting blood) ·       Agitation, restlessness ·       Dilated pupils ·       Sinus tachycardia, ventricular arrhythmias ·       Hyperglycaemia ·       Convulsions |
1 inch = 2.54cm 12 inches = 1 feet IBW (female) = 45.5kg + 2.3kg for each inch over 5ft Theophylline clearance = 0.04 L/hour per kg IBW x 1.6 |
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Written by Fatima Sazzad, GPhC Reg No. 2212805